Plasmid DNA

Development & Manufacturing of RUO, High-Quality & GMP Materials

Bionova Scientific offers development and manufacturing of plasmid DNA (pDNA), including:

  • Research Use Only (RUO)
  • High-Quality (HQ)
  • GMP

Committed to delivering the pDNA you need… When you need it.

If you are developing cell therapies (Autologous, CAR-T, Allogenic), gene therapies (AAV), or mRNA based therapies and need plasmid DNA for research, pre-clinical or clinical programs turn to Bionova Scientific.

Building Blocks for Better Treatments

Our experienced team was assembled from the best and the brightest from some of the industry’s scientific powerhouses. We understand the urgency you face and can deliver the pDNA you need with project lead-times that will keep your program on track.

High throughput protein production platform

Centrally Located State-of-the-Art Facility

Our centralized pDNA Process Development & Manufacturing facility is located in The Woodlands, Texas (near Houston). This flexible, multimodal operation features 10,000 sq. ft. of state-of-the-art technologies. Current capabilities include:

  • 2 L scale fermentation (RUO)
  • 50 L scale fermentation (HQ/GMP)
  • Active plans to scale

Best-in-Class Technology Stack

Our pDNA technology stack is built on a foundation of core, cutting edge technologies:

Reliable, Reproducible Process: Ultra Yield® and Plasmid+® System from Thomson

Off-the-Shelf and Plasmid Design: Syenex OTS LVV System:

  • SNX-T1 Enhancer
  • SNX-VSVG
  • SN-Gagpol
  • SNX-Rev
  • SNX-GOI

Advanced Host Tools: Scarab’s Clean Genome® E. coli

Flexible Assets: Cytiva’s FlexFactory™ SIngle-Use Platform

Protein production purification equipment

Summary of Service Offerings

Strain Development

  • Transformation and Screening
  • RCB & MCB Banking, Stability and Characterization

Process Development

  • Upstream & Downstream
  • Shaker Flask and Fed-Batch
  • Platform and Custom Optionality

Method Development

  • Development and/or Verification of Bionova Platform Processes for Your Plasmid
  • Qualification

Formulation Development

  • Platform and Custom Optionality

RUO Material Production

  • 10 mg Batch Size (Nominal) from 8 to 10 g Paste (Nominal

HQ GMP Manufacture

  • 0.5 g Batch Size, AD Testing Package
  • 5 g Batch Size, AD Testing Package

GMP Manufacture

  • 0.5 g Batch Size, QC Testing Package, QA Release
    5 g Batch Size, AD Testing Package, QA Release

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